A doctor-assisted virtual clinic led by Dr. Danilo Buonsenso, MD PhD — one of the world's leading researchers in Long COVID and ME/CFS in both adults and children. Complete internationally validated clinical scales from anywhere in the world, and receive a personalised specialist assessment supported by AI, under Dr. Buonsenso's direct supervision.
Available for adult patients (18+) and children (under 18) · International patients welcome
Dr. Buonsenso's regularly updated blog covering the latest research, clinical thinking, and real-world insights on Long COVID and ME/CFS — written for patients and professionals. Subscribe free to follow new posts.
Dr. Buonsenso's book on Long COVID — from the beginnings and background to the current understanding of the condition. An essential, accessible read that explains his clinical approach, the science behind ME/CFS and Long COVID, and what to expect from specialist care.
You do not need to travel to Rome, wait months for an NHS or public health referral, or explain your full history from scratch in a 10-minute appointment. The intake captures everything a specialist would want to know — your complete medical history, every medication tried, all investigations, and full validated symptom profiles — giving Dr. Buonsenso the information he needs before your consultation even begins.
The outcome scales in this platform are not questionnaires invented for this website. They are internationally validated tools established by rigorous scientific consensus involving hundreds of clinicians, researchers, and patients worldwide. This means your scores are comparable to research data, clinically meaningful, and recognised by specialists globally. This is the same level of assessment used in leading Long COVID research centres.
One of the most significant problems in Long COVID and ME/CFS care is the lack of objective, comparable measurements over time. By completing these validated scales at the start of your care, you establish a documented, scientifically rigorous baseline. Future assessments — whether in 3 months, 6 months, or 2 years — can be directly compared against these scores to objectively track improvement, deterioration, or response to treatment. This turns your clinical story into data.
With your optional consent, your anonymised data can contribute to ongoing research led by Dr. Buonsenso and collaborating institutions. Long COVID and ME/CFS research is still in a critical phase — patient data collected using validated instruments is exactly what is needed to understand the condition better, identify subtypes, and develop effective treatments. You can also consent to be contacted about future clinical trials you may be eligible for.
Send a voluntary contribution (€5 or multiples) to Dr. Buonsenso via Revolut (@danilo8rht) or Bitcoin. Any amount is welcome.
Message Dr. Buonsenso via Substack or email. He will send you a secure link and your personal single-use password — usually within 48 hours.
Fill in your full clinical history and all validated outcome scales at your own pace. Your scores are calculated automatically. Upload your documents.
An AI-assisted referral letter is generated under Dr. Buonsenso's supervision. Send it to him and agree a consultation time.
Covers all 12 domains of the internationally validated PC-COS adult core outcome set: fatigue, pain, post-exertional symptoms, cardiovascular, respiratory (MRC Dyspnoea Scale), nervous system, cognitive function, mental health, physical functioning, and work/study impact.
Completed by a parent or legal guardian. Uses the PC-COS Children outcome set with validated instruments: PedsQL™ Fatigue, PedsQL™ GI, PedsQL™ Cognitive, and EQ-5D Family — plus cardiovascular and school/social impact domains.
Every scale used in this platform was established by rigorous international Delphi consensus. Dr. Buonsenso is a co-author on both consensus studies — meaning the tools in this intake reflect his own scientific contributions to the field.
12 core outcomes for Long COVID in adults — Delphi consensus involving 1,535 participants from 71 countries. Covers fatigue, pain, post-exertion symptoms, cardiovascular (palpitations, POTS, chest symptoms), respiratory (MRC Dyspnoea Scale), neurological, cognitive, mental health, sleep, physical functioning, and work/study changes. Automatically scored by domain with totals and severity labels.
Munblit et al., Lancet Respir Med 2022 · PMID 35714658
7 core domains for Long COVID in children with consensus-validated instruments: PedsQL™ Multidimensional Fatigue Scale, PedsQL™ GI Symptom Scales, PedsQL™ Cognitive Functioning Scale, EQ-5D Family with VAS — plus cardiovascular and school/study/social change domains. Scores converted to 0–100 scale per PedsQL™ scoring convention.
Seylanova, Buonsenso et al., Eur Respir J 2024 · PMID 38359962
9-item validated scale measuring PEM — the hallmark feature of ME/CFS and a key feature of Long COVID. Total score /36 with severity classification, plus detailed assessment of triggers, delay to onset, and episode duration. Included for all patients regardless of age or pathway. Used as both a diagnostic and longitudinal monitoring tool.
Core outcome for ME/CFS and Long COVID · All ages
The letter is addressed directly to Dr. Buonsenso and written as a formal medical document. It includes your full clinical summary, all validated domain scores with totals and denominators, your PEM score /36 with severity and worst-rated items highlighted, key medications and their effects, a list of uploaded documents, and your specific questions for Dr. Buonsenso.
The letter cites the relevant scientific references (Munblit et al. 2022 or Seylanova/Buonsenso et al. 2024) and is formatted so that Dr. Buonsenso can immediately use it to prepare for your consultation — and as a dated, scored baseline record of your condition at the time of first assessment.
Access is immediate — no password needed, no waiting. You receive a unique personal code. Save it to return for follow-up assessments in future months.
Fill in your full history and all validated outcome scales at your own pace, in your chosen language (IT/EN/FR/ES). Scores are calculated automatically.
An AI-assisted letter is generated under Dr. Buonsenso's direct supervision. Email it to danilo.buonsenso@policlinicogemelli.it to agree a consultation time.
A voluntary donation of any amount helps cover the costs of running this platform — server, AI API calls, and development. Pay what you can, when you can.
Copy address to your wallet
No donation required to use the platform. If you cannot afford to donate at this time, please complete the form anyway — access to specialist knowledge should not depend on financial means.
Enter your name and email. You will receive a unique personal code — save it to access your follow-up assessment in future.
Returning patient? Enter your code for follow-up
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Select whether this form is for an adult patient (18+) or a child or young person (under 18). For children, the form should be completed by a parent or legal guardian.
PC-COS adult core outcome set · Munblit et al., Lancet Respir Med 2022
PC-COS Children outcome set · Seylanova & Buonsenso et al., ERJ 2024
Suggested amounts (click to select, then pay via your preferred method below):
Any amount is welcome — including smaller amounts. Your contribution directly supports the platform, the AI infrastructure, and Dr. Buonsenso's ongoing Long COVID and ME/CFS research.
Works with or without a Revolut account — accepts any currency
Pay via Revolut →Send via PayPal to the email above — select "Sending to a friend"
Pay via PayPal →Copy the address and send from any Bitcoin wallet
When you email your referral letter to danilo.buonsenso@policlinicogemelli.it, please attach any of the following that you have: